About Ras-related protein Rab-8A
Ras-related protein Rab-8A (RAB8A) is a protein
from Homo sapiens identified by UniProt accession
P61006, 207 residues long.
MolForge cross-references it against 0 known binders and
130 disease associations.
Target properties
| Protein name | Ras-related protein Rab-8A |
|---|
| UniProt accession | P61006 |
|---|
| Gene | RAB8A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 207 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (130)
Diseases linked to this target (Open Targets).
- platelet count · score 0.25
- low grade glioma · score 0.23
- Red cell distribution width · score 0.22
- mean corpuscular hemoglobin concentration · score 0.21
- mean platelet volume · score 0.20
- mean corpuscular hemoglobin · score 0.15
- mean corpuscular volume · score 0.14
- myeloperoxidase measurement · score 0.11
- non-small cell lung carcinoma · score 0.07
- Diarrhea, Infantile · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P61006-F1 | alphafold | PREDICTED | 85.41 | — |
Amino-acid sequence (207 residues)
MAKTYDYLFK LLLIGDSGVG KTCVLFRFSE DAFNSTFIST IGIDFKIRTI ELDGKRIKLQ IWDTAGQERF RTITTAYYRG AMGIMLVYDI TNEKSFDNIR NWIRNIEEHA SADVEKMILG NKCDVNDKRQ VSKERGEKLA LDYGIKFMET SAKANINVEN AFFTLARDIK AKMDKKLEGN SPQGSNQGVK ITPDQQKRSS FFRCVLL
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