About Ras-related protein Rab-5B
Ras-related protein Rab-5B (RAB5B) is a protein
from Homo sapiens identified by UniProt accession
P61020, 215 residues long.
MolForge cross-references it against 0 known binders and
133 disease associations.
Target properties
| Protein name | Ras-related protein Rab-5B |
|---|
| UniProt accession | P61020 |
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| Gene | RAB5B |
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| Organism | Homo sapiens |
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| Length | 215 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (133)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- hypothyroidism · score 0.21
- gastroesophageal reflux disease · score 0.20
- type 1 diabetes mellitus · score 0.20
- Peptic ulcer and gastro-oesophageal reflux disease (GORD) drug use measurement · score 0.19
- eosinophil count · score 0.18
- Nasal Cavity Polyp · score 0.17
- autoimmune disease · score 0.17
- childhood onset asthma · score 0.16
- polycystic ovary syndrome · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P61020-F1 | alphafold | PREDICTED | 85.76 | — |
Amino-acid sequence (215 residues)
MTSRSTARPN GQPQASKICQ FKLVLLGESA VGKSSLVLRF VKGQFHEYQE STIGAAFLTQ SVCLDDTTVK FEIWDTAGQE RYHSLAPMYY RGAQAAIVVY DITNQETFAR AKTWVKELQR QASPSIVIAL AGNKADLANK RMVEYEEAQA YADDNSLLFM ETSAKTAMNV NDLFLAIAKK LPKSEPQNLG GAAGRSRGVD LHEQSQQNKS QCCSN
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