C-X-C chemokine receptor type 4 (CXCR4)

About C-X-C chemokine receptor type 4

C-X-C chemokine receptor type 4 (CXCR4) is a protein from Homo sapiens identified by UniProt accession P61073, 352 residues long. MolForge cross-references it against 0 known binders and 1,311 disease associations.

Target properties

Protein name	C-X-C chemokine receptor type 4
UniProt accession	P61073
Gene	CXCR4
Organism	Homo sapiens
Length	352 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (4)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (1311)

Diseases linked to this target (Open Targets).

WHIM syndrome · score 0.79
monocyte count · score 0.66
multiple myeloma · score 0.63
neutrophil count · score 0.58
leukocyte count · score 0.57
HIV infection · score 0.56
non-Hodgkins lymphoma · score 0.53
lymphoma · score 0.52
severe congenital neutropenia · score 0.46
monocyte percentage of leukocytes · score 0.43

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P61073-F1	alphafold	PREDICTED	82.26	—

Amino-acid sequence (352 residues)

MEGISIYTSD NYTEEMGSGD YDSMKEPCFR EENANFNKIF LPTIYSIIFL TGIVGNGLVI LVMGYQKKLR SMTDKYRLHL SVADLLFVIT LPFWAVDAVA NWYFGNFLCK AVHVIYTVNL YSSVLILAFI SLDRYLAIVH ATNSQRPRKL LAEKVVYVGV WIPALLLTIP DFIFANVSEA DDRYICDRFY PNDLWVVVFQ FQHIMVGLIL PGIVILSCYC IIISKLSHSK GHQKRKALKT TVILILAFFA CWLPYYIGIS IDSFILLEII KQGCEFENTV HKWISITEAL AFFHCCLNPI LYAFLGAKFK TSAQHALTSV SRGSSLKILS KGKRGGHSSV STESESSSFH SS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards