Ubiquitin-conjugating enzyme E2 D3 (UBE2D3)

About Ubiquitin-conjugating enzyme E2 D3

Ubiquitin-conjugating enzyme E2 D3 (UBE2D3) is a protein from Homo sapiens identified by UniProt accession P61077, 147 residues long. MolForge cross-references it against 0 known binders and 100 disease associations.

Target properties

Protein name	Ubiquitin-conjugating enzyme E2 D3
UniProt accession	P61077
Gene	UBE2D3
Organism	Homo sapiens
Length	147 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (100)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.35
clear cell renal carcinoma · score 0.26
eosinophil count · score 0.26
lymphocyte count · score 0.26
refractive error measurement · score 0.24
glomerular filtration rate · score 0.23
blood protein measurement · score 0.22
creatinine measurement · score 0.20
cystatin C measurement · score 0.20
Red cell distribution width · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P61077-F1	alphafold	PREDICTED	96.38	—

Amino-acid sequence (147 residues)

MALKRINKEL SDLARDPPAQ CSAGPVGDDM FHWQATIMGP NDSPYQGGVF FLTIHFPTDY PFKPPKVAFT TRIYHPNINS NGSICLDILR SQWSPALTIS KVLLSICSLL CDPNPDDPLV PEIARIYKTD RDKYNRISRE WTQKYAM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards