About NEDD8-conjugating enzyme Ubc12
NEDD8-conjugating enzyme Ubc12 (UBE2M) is a protein
from Homo sapiens identified by UniProt accession
P61081, 183 residues long.
MolForge cross-references it against 0 known binders and
85 disease associations.
Target properties
| Protein name | NEDD8-conjugating enzyme Ubc12 |
|---|
| UniProt accession | P61081 |
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| Gene | UBE2M |
|---|
| Organism | Homo sapiens |
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| Length | 183 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (85)
Diseases linked to this target (Open Targets).
- colorectal cancer · score 0.11
- colorectal adenoma · score 0.11
- sex hormone-binding globulin measurement · score 0.11
- mean corpuscular hemoglobin concentration · score 0.10
- hepatocellular carcinoma · score 0.10
- platelet count · score 0.09
- neoplasm · score 0.09
- colorectal carcinoma · score 0.07
- low density lipoprotein cholesterol measurement · score 0.07
- Red cell distribution width · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P61081-F1 | alphafold | PREDICTED | 91.36 | — |
Amino-acid sequence (183 residues)
MIKLFSLKQQ KKEEESAGGT KGSSKKASAA QLRIQKDINE LNLPKTCDIS FSDPDDLLNF KLVICPDEGF YKSGKFVFSF KVGQGYPHDP PKVKCETMVY HPNIDLEGNV CLNILREDWK PVLTINSIIY GLQYLFLEPN PEDPLNKEAA EVLQNNRRLF EQNVQRSMRG GYIGSTYFER CLK
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