Ubiquitin-conjugating enzyme E2 N (UBE2N)

About Ubiquitin-conjugating enzyme E2 N

Ubiquitin-conjugating enzyme E2 N (UBE2N) is a protein from Homo sapiens identified by UniProt accession P61088, 152 residues long. MolForge cross-references it against 0 known binders and 112 disease associations.

Target properties

Protein name	Ubiquitin-conjugating enzyme E2 N
UniProt accession	P61088
Gene	UBE2N
Organism	Homo sapiens
Length	152 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (112)

Diseases linked to this target (Open Targets).

platelet count · score 0.43
Red cell distribution width · score 0.40
mean corpuscular hemoglobin concentration · score 0.38
mean reticulocyte volume · score 0.33
platelet crit · score 0.32
lung adenocarcinoma · score 0.29
endometrial cancer · score 0.27
esophageal cancer · score 0.26
clear cell renal carcinoma · score 0.26
mean corpuscular hemoglobin · score 0.25

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P61088-F1	alphafold	PREDICTED	95.68	—

Amino-acid sequence (152 residues)

MAGLPRRIIK ETQRLLAEPV PGIKAEPDES NARYFHVVIA GPQDSPFEGG TFKLELFLPE EYPMAAPKVR FMTKIYHPNV DKLGRICLDI LKDKWSPALQ IRTVLLSIQA LLSAPNPDDP LANDVAEQWK TNEAQAIETA RAWTRLYAMN NI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards