About Actin-related protein 3
Actin-related protein 3 (ACTR3) is a protein
from Homo sapiens identified by UniProt accession
P61158, 418 residues long.
MolForge cross-references it against 0 known binders and
58 disease associations.
Target properties
| Protein name | Actin-related protein 3 |
|---|
| UniProt accession | P61158 |
|---|
| Gene | ACTR3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 418 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (58)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- BMI-adjusted waist-hip ratio · score 0.42
- serum alanine aminotransferase measurement · score 0.42
- BMI-adjusted waist circumference · score 0.37
- waist-hip ratio · score 0.37
- cutaneous Leishmaniasis · score 0.37
- corneal endothelial cell measurement · score 0.30
- metabolite measurement · score 0.25
- sex hormone-binding globulin measurement · score 0.21
- aspartate aminotransferase measurement · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P61158-F1 | alphafold | PREDICTED | 91.33 | — |
Amino-acid sequence (418 residues)
MAGRLPACVV DCGTGYTKLG YAGNTEPQFI IPSCIAIKES AKVGDQAQRR VMKGVDDLDF FIGDEAIEKP TYATKWPIRH GIVEDWDLME RFMEQVIFKY LRAEPEDHYF LLTEPPLNTP ENREYTAEIM FESFNVPGLY IAVQAVLALA ASWTSRQVGE RTLTGTVIDS GDGVTHVIPV AEGYVIGSCI KHIPIAGRDI TYFIQQLLRD REVGIPPEQS LETAKAVKER YSYVCPDLVK EFNKYDTDGS KWIKQYTGIN AISKKEFSID VGYERFLGPE IFFHPEFANP DFTQPISEVV DEVIQNCPID VRRPLYKNIV LSGGSTMFRD FGRRLQRDLK RTVDARLKLS EELSGGRLKP KPIDVQVITH HMQRYAVWFG GSMLASTPEF YQVCHTKKDY EEIGPSICRH NPVFGVMS
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