Actin-related protein 2 (ACTR2)

About Actin-related protein 2

Actin-related protein 2 (ACTR2) is a protein from Homo sapiens identified by UniProt accession P61160, 394 residues long. MolForge cross-references it against 0 known binders and 106 disease associations.

Target properties

Protein name	Actin-related protein 2
UniProt accession	P61160
Gene	ACTR2
Organism	Homo sapiens
Length	394 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (106)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.55
neuroinflammatory disorder · score 0.37
cutaneous Leishmaniasis · score 0.37
heel bone mineral density · score 0.35
Alzheimer disease · score 0.31
Parkinson disease · score 0.31
multiple sclerosis · score 0.31
lysosomal storage disease · score 0.31
lung adenocarcinoma · score 0.29
psoriasis · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P61160-F1	alphafold	PREDICTED	93.89	—

Amino-acid sequence (394 residues)

MDSQGRKVVV CDNGTGFVKC GYAGSNFPEH IFPALVGRPI IRSTTKVGNI EIKDLMVGDE ASELRSMLEV NYPMENGIVR NWDDMKHLWD YTFGPEKLNI DTRNCKILLT EPPMNPTKNR EKIVEVMFET YQFSGVYVAI QAVLTLYAQG LLTGVVVDSG DGVTHICPVY EGFSLPHLTR RLDIAGRDIT RYLIKLLLLR GYAFNHSADF ETVRMIKEKL CYVGYNIEQE QKLALETTVL VESYTLPDGR IIKVGGERFE APEALFQPHL INVEGVGVAE LLFNTIQAAD IDTRSEFYKH IVLSGGSTMY PGLPSRLERE LKQLYLERVL KGDVEKLSKF KIRIEDPPRR KHMVFLGGAV LADIMKDKDN FWMTRQEYQE KGVRVLEKLG VTVR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards