About Alpha-centractin
Alpha-centractin (ACTR1A) is a protein
from Homo sapiens identified by UniProt accession
P61163, 376 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | Alpha-centractin |
|---|
| UniProt accession | P61163 |
|---|
| Gene | ACTR1A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 376 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (71)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.29
- alkaline phosphatase measurement · score 0.26
- body mass index · score 0.25
- ovarian cancer · score 0.23
- breast adenocarcinoma · score 0.23
- erythrocyte count · score 0.22
- insomnia measurement · score 0.20
- platelet count · score 0.15
- medulloblastoma · score 0.15
- insomnia · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P61163-F1 | alphafold | PREDICTED | 92.96 | — |
Amino-acid sequence (376 residues)
MESYDVIANQ PVVIDNGSGV IKAGFAGDQI PKYCFPNYVG RPKHVRVMAG ALEGDIFIGP KAEEHRGLLS IRYPMEHGIV KDWNDMERIW QYVYSKDQLQ TFSEEHPVLL TEAPLNPRKN RERAAEVFFE TFNVPALFIS MQAVLSLYAT GRTTGVVLDS GDGVTHAVPI YEGFAMPHSI MRIDIAGRDV SRFLRLYLRK EGYDFHSSSE FEIVKAIKER ACYLSINPQK DETLETEKAQ YYLPDGSTIE IGPSRFRAPE LLFRPDLIGE ESEGIHEVLV FAIQKSDMDL RRTLFSNIVL SGGSTLFKGF GDRLLSEVKK LAPKDVKIRI SAPQERLYST WIGGSILASL DTFKKMWVSK KEYEEDGARS IHRKTF
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