COP9 signalosome complex subunit 2 (COPS2)

About COP9 signalosome complex subunit 2

COP9 signalosome complex subunit 2 (COPS2) is a protein from Homo sapiens identified by UniProt accession P61201, 443 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

Target properties

Protein name	COP9 signalosome complex subunit 2
UniProt accession	P61201
Gene	COPS2
Organism	Homo sapiens
Length	443 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (48)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.45
lung adenocarcinoma · score 0.21
low grade glioma · score 0.18
breast adenocarcinoma · score 0.18
mean platelet volume · score 0.12
low density lipoprotein cholesterol measurement · score 0.09
cortical thickness · score 0.08
cancer · score 0.08
thyroid stimulating hormone measurement · score 0.07
hormone measurement · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P61201-F1	alphafold	PREDICTED	85.13	—

Amino-acid sequence (443 residues)

MSDMEDDFMC DDEEDYDLEY SEDSNSEPNV DLENQYYNSK ALKEDDPKAA LSSFQKVLEL EGEKGEWGFK ALKQMIKINF KLTNFPEMMN RYKQLLTYIR SAVTRNYSEK SINSILDYIS TSKQMDLLQE FYETTLEALK DAKNDRLWFK TNTKLGKLYL EREEYGKLQK ILRQLHQSCQ TDDGEDDLKK GTQLLEIYAL EIQMYTAQKN NKKLKALYEQ SLHIKSAIPH PLIMGVIREC GGKMHLREGE FEKAHTDFFE AFKNYDESGS PRRTTCLKYL VLANMLMKSG INPFDSQEAK PYKNDPEILA MTNLVSAYQN NDITEFEKIL KTNHSNIMDD PFIREHIEEL LRNIRTQVLI KLIKPYTRIH IPFISKELNI DVADVESLLV QCILDNTIHG RIDQVNQLLE LDHQKRGGAR YTALDKWTNQ LNSLNQAVVS KLA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards