About ADP-ribosylation factor 3
ADP-ribosylation factor 3 (ARF3) is a protein
from Homo sapiens identified by UniProt accession
P61204, 181 residues long.
MolForge cross-references it against 0 known binders and
170 disease associations.
Target properties
| Protein name | ADP-ribosylation factor 3 |
|---|
| UniProt accession | P61204 |
|---|
| Gene | ARF3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 181 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (170)
Diseases linked to this target (Open Targets).
- Intellectual disability · score 0.63
- Microcephaly · score 0.62
- Seizure · score 0.61
- Global developmental delay · score 0.57
- Atrophy/Degeneration affecting the central nervous system · score 0.51
- microcephaly · score 0.50
- Morphological central nervous system abnormality · score 0.50
- scoliosis · score 0.45
- Hypotonia · score 0.43
- Dystonia · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P61204-F1 | alphafold | PREDICTED | 86.12 | — |
Amino-acid sequence (181 residues)
MGNIFGNLLK SLIGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV NEAREELMRM LAEDELRDAV LLVFANKQDL PNAMNAAEIT DKLGLHSLRH RNWYIQATCA TSGDGLYEGL DWLANQLKNK K
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