DNA-directed RNA polymerases I, II, and III subunit RPABC2 (POLR2F)

About DNA-directed RNA polymerases I, II, and III subunit RPABC2

DNA-directed RNA polymerases I, II, and III subunit RPABC2 (POLR2F) is a protein from Homo sapiens identified by UniProt accession P61218, 127 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.

Target properties

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Disease associations (62)

Diseases linked to this target (Open Targets).

• HIV infection · score 0.60
• Neurologic Waardenburg-Shah syndrome · score 0.55
• PCWH syndrome · score 0.55
• Waardenburg syndrome type 2E · score 0.55
• Waardenburg-Shah syndrome · score 0.55
• Waardenburg syndrome · score 0.52
• Waardenburg syndrome type 1 · score 0.50
• Hirschsprung disease · score 0.44
• Rare genetic deafness · score 0.44
• Waardenburg syndrome type 4A · score 0.42

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Amino-acid sequence (127 residues)

External references