About ATP-binding cassette sub-family E member 1
ATP-binding cassette sub-family E member 1 (ABCE1) is a protein
from Homo sapiens identified by UniProt accession
P61221, 599 residues long.
MolForge cross-references it against 0 known binders and
109 disease associations.
Target properties
| Protein name | ATP-binding cassette sub-family E member 1 |
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| UniProt accession | P61221 |
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| Gene | ABCE1 |
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| Organism | Homo sapiens |
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| Length | 599 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (109)
Diseases linked to this target (Open Targets).
- neuroinflammatory disorder · score 0.37
- neurodegenerative disease · score 0.28
- reticulocyte count · score 0.27
- body height · score 0.20
- mean corpuscular volume · score 0.19
- mean reticulocyte volume · score 0.18
- mean corpuscular hemoglobin concentration · score 0.17
- body weight · score 0.17
- heel bone mineral density · score 0.15
- appendicular lean mass · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P61221-F1 | alphafold | PREDICTED | 86.69 | — |
Amino-acid sequence (599 residues)
MADKLTRIAI VNHDKCKPKK CRQECKKSCP VVRMGKLCIE VTPQSKIAWI SETLCIGCGI CIKKCPFGAL SIVNLPSNLE KETTHRYCAN AFKLHRLPIP RPGEVLGLVG TNGIGKSTAL KILAGKQKPN LGKYDDPPDW QEILTYFRGS ELQNYFTKIL EDDLKAIIKP QYVDQIPKAA KGTVGSILDR KDETKTQAIV CQQLDLTHLK ERNVEDLSGG ELQRFACAVV CIQKADIFMF DEPSSYLDVK QRLKAAITIR SLINPDRYII VVEHDLSVLD YLSDFICCLY GVPSAYGVVT MPFSVREGIN IFLDGYVPTE NLRFRDASLV FKVAETANEE EVKKMCMYKY PGMKKKMGEF ELAIVAGEFT DSEIMVMLGE NGTGKTTFIR MLAGRLKPDE GGEVPVLNVS YKPQKISPKS TGSVRQLLHE KIRDAYTHPQ FVTDVMKPLQ IENIIDQEVQ TLSGGELQRV ALALCLGKPA DVYLIDEPSA YLDSEQRLMA ARVVKRFILH AKKTAFVVEH DFIMATYLAD RVIVFDGVPS KNTVANSPQT LLAGMNKFLS QLEITFRRDP NNYRPRINKL NSIKDVEQKK SGNYFFLDD
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