About Proteasome activator complex subunit 3
Proteasome activator complex subunit 3 (PSME3) is a protein
from Homo sapiens identified by UniProt accession
P61289, 254 residues long.
MolForge cross-references it against 0 known binders and
255 disease associations.
Target properties
| Protein name | Proteasome activator complex subunit 3 |
|---|
| UniProt accession | P61289 |
|---|
| Gene | PSME3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 254 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (255)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.46
- neurodegenerative disease · score 0.37
- breast adenocarcinoma · score 0.30
- head and neck squamous cell carcinoma · score 0.28
- squamous cell lung carcinoma · score 0.28
- gastric adenocarcinoma · score 0.27
- clear cell renal carcinoma · score 0.27
- prostate adenocarcinoma · score 0.16
- cancer · score 0.10
- lung adenocarcinoma · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P61289-F1 | alphafold | PREDICTED | 87.35 | — |
Amino-acid sequence (254 residues)
MASLLKVDQE VKLKVDSFRE RITSEAEDLV ANFFPKKLLE LDSFLKEPIL NIHDLTQIHS DMNLPVPDPI LLTNSHDGLD GPTYKKRRLD ECEEAFQGTK VFVMPNGMLK SNQQLVDIIE KVKPEIRLLI EKCNTVKMWV QLLIPRIEDG NNFGVSIQEE TVAELRTVES EAASYLDQIS RYYITRAKLV SKIAKYPHVE DYRRTVTEID EKEYISLRLI ISELRNQYVT LHDMILKNIE KIKRPRSSNA ETLY
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