About Heart- and neural crest derivatives-expressed protein 2
Heart- and neural crest derivatives-expressed protein 2 (HAND2) is a protein
from Homo sapiens identified by UniProt accession
P61296, 217 residues long.
MolForge cross-references it against 0 known binders and
249 disease associations.
Target properties
| Protein name | Heart- and neural crest derivatives-expressed protein 2 |
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| UniProt accession | P61296 |
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| Gene | HAND2 |
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| Organism | Homo sapiens |
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| Length | 217 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (249)
Diseases linked to this target (Open Targets).
- atrial fibrillation · score 0.49
- electrocardiography · score 0.41
- familial isolated dilated cardiomyopathy · score 0.37
- vital capacity · score 0.35
- platelet count · score 0.34
- dilated cardiomyopathy 1A · score 0.34
- cardiac arrhythmia · score 0.33
- Inguinal hernia · score 0.32
- platelet crit · score 0.32
- pulse pressure measurement · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P61296-F1 | alphafold | PREDICTED | 66.42 | — |
Amino-acid sequence (217 residues)
MSLVGGFPHH PVVHHEGYPF AAAAAAAAAA AASRCSHEEN PYFHGWLIGH PEMSPPDYSM ALSYSPEYAS GAAGLDHSHY GGVPPGAGPP GLGGPRPVKR RGTANRKERR RTQSINSAFA ELRECIPNVP ADTKLSKIKT LRLATSYIAY LMDLLAKDDQ NGEAEAFKAE IKKTDVKEEK RKKELNEILK STVSSNDKKT KGRTGWPQHV WALELKQ
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