About Fibroblast growth factor 12
Fibroblast growth factor 12 (FGF12) is a protein
from Homo sapiens identified by UniProt accession
P61328, 243 residues long.
MolForge cross-references it against 0 known binders and
105 disease associations.
Target properties
| Protein name | Fibroblast growth factor 12 |
|---|
| UniProt accession | P61328 |
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| Gene | FGF12 |
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| Organism | Homo sapiens |
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| Length | 243 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (105)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy · score 0.59
- neurodegenerative disease · score 0.47
- Epileptic encephalopathy · score 0.46
- undetermined early-onset epileptic encephalopathy · score 0.37
- PR interval · score 0.36
- protein measurement · score 0.36
- Seizure · score 0.34
- mathematical ability · score 0.28
- neurofibrillary tangles measurement · score 0.27
- genetic disorder · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P61328-F1 | alphafold | PREDICTED | 77.34 | — |
Amino-acid sequence (243 residues)
MAAAIASSLI RQKRQARESN SDRVSASKRR SSPSKDGRSL CERHVLGVFS KVRFCSGRKR PVRRRPEPQL KGIVTRLFSQ QGYFLQMHPD GTIDGTKDEN SDYTLFNLIP VGLRVVAIQG VKASLYVAMN GEGYLYSSDV FTPECKFKES VFENYYVIYS STLYRQQESG RAWFLGLNKE GQIMKGNRVK KTKPSSHFVP KPIEVCMYRE PSLHEIGEKQ GRSRKSSGTP TMNGGKVVNQ DST
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