Large ribosomal subunit protein eL27 (RPL27)

About Large ribosomal subunit protein eL27

Large ribosomal subunit protein eL27 (RPL27) is a protein from Homo sapiens identified by UniProt accession P61353, 136 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.

Target properties

Protein name	Large ribosomal subunit protein eL27
UniProt accession	P61353
Gene	RPL27
Organism	Homo sapiens
Length	136 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (58)

Diseases linked to this target (Open Targets).

Duchenne muscular dystrophy · score 0.50
cystic fibrosis · score 0.50
Blackfan-Diamond anemia · score 0.49
influenza · score 0.46
Diamond-Blackfan anemia · score 0.44
Becker muscular dystrophy · score 0.29
clear cell renal carcinoma · score 0.27
qualitative or quantitative defects of dystrophin · score 0.26
aniridia · score 0.09
diffuse large B-cell lymphoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P61353-F1	alphafold	PREDICTED	94.32	—

Amino-acid sequence (136 residues)

MGKFMKPGKV VLVLAGRYSG RKAVIVKNID DGTSDRPYSH ALVAGIDRYP RKVTAAMGKK KIAKRSKIKS FVKVYNYNHL MPTRYSVDIP LDKTVVNKDV FRDPALKRKA RREAKVKFEE RYKTGKNKWF FQKLRF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards