V-type proton ATPase subunit d 1 (ATP6V0D1)

About V-type proton ATPase subunit d 1

V-type proton ATPase subunit d 1 (ATP6V0D1) is a protein from Homo sapiens identified by UniProt accession P61421, 351 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.

Target properties

Protein name	V-type proton ATPase subunit d 1
UniProt accession	P61421
Gene	ATP6V0D1
Organism	Homo sapiens
Length	351 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (62)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
FEV/FVC ratio · score 0.16
glioblastoma multiforme · score 0.14
mean platelet volume · score 0.13
Agouti-related protein measurement · score 0.11
mean corpuscular hemoglobin · score 0.06
vital capacity · score 0.05
mean corpuscular hemoglobin concentration · score 0.04
BMI-adjusted waist-hip ratio · score 0.04
hemoglobin D disease · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P61421-F1	alphafold	PREDICTED	85.89	—

Amino-acid sequence (351 residues)

MSFFPELYFN VDNGYLEGLV RGLKAGVLSQ ADYLNLVQCE TLEDLKLHLQ STDYGNFLAN EASPLTVSVI DDRLKEKMVV EFRHMRNHAY EPLASFLDFI TYSYMIDNVI LLITGTLHQR SIAELVPKCH PLGSFEQMEA VNIAQTPAEL YNAILVDTPL AAFFQDCISE QDLDEMNIEI IRNTLYKAYL ESFYKFCTLL GGTTADAMCP ILEFEADRRA FIITINSFGT ELSKEDRAKL FPHCGRLYPE GLAQLARADD YEQVKNVADY YPEYKLLFEG AGSNPGDKTL EDRFFEHEVK LNKLAFLNQF HFGVFYAFVK LKEQECRNIV WIAECIAQRH RAKIDNYIPI F

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards