Pterin-4-alpha-carbinolamine dehydratase (PCBD1)

About Pterin-4-alpha-carbinolamine dehydratase

Pterin-4-alpha-carbinolamine dehydratase (PCBD1) is a protein from Homo sapiens identified by UniProt accession P61457, 104 residues long. MolForge cross-references it against 0 known binders and 90 disease associations.

Target properties

Protein name	Pterin-4-alpha-carbinolamine dehydratase
UniProt accession	P61457
Gene	PCBD1
Organism	Homo sapiens
Length	104 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (90)

Diseases linked to this target (Open Targets).

Hyperphenylalaninemia · score 0.79
pterin-4 alpha-carbinolamine dehydratase 1 deficiency · score 0.75
Dehydratase deficiency · score 0.68
type 2 diabetes mellitus · score 0.26
Red cell distribution width · score 0.25
blood protein measurement · score 0.19
smoking status measurement · score 0.18
reticulocyte count · score 0.18
lymphocyte count · score 0.17
metabolite measurement · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P61457-F1	alphafold	PREDICTED	96.24	—

Amino-acid sequence (104 residues)

MAGKAHRLSA EERDQLLPNL RAVGWNELEG RDAIFKQFHF KDFNRAFGFM TRVALQAEKL DHHPEWFNVY NKVHITLSTH ECAGLSERDI NLASFIEQVA VSMT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards