About Rho-related GTP-binding protein RhoE
Rho-related GTP-binding protein RhoE (RND3) is a protein
from Homo sapiens identified by UniProt accession
P61587, 244 residues long.
MolForge cross-references it against 0 known binders and
206 disease associations.
Target properties
| Protein name | Rho-related GTP-binding protein RhoE |
|---|
| UniProt accession | P61587 |
|---|
| Gene | RND3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 244 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (206)
Diseases linked to this target (Open Targets).
- reticulocyte measurement · score 0.40
- Immature Reticulocyte Fraction Measurement · score 0.37
- reticulocyte count · score 0.34
- urate measurement · score 0.32
- bone density · score 0.32
- body mass index · score 0.31
- cortical surface area measurement · score 0.29
- diet measurement · score 0.26
- daytime rest measurement · score 0.25
- type 2 diabetes mellitus · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P61587-F1 | alphafold | PREDICTED | 81.74 | — |
Amino-acid sequence (244 residues)
MKERRASQKL SSKSIMDPNQ NVKCKIVVVG DSQCGKTALL HVFAKDCFPE NYVPTVFENY TASFEIDTQR IELSLWDTSG SPYYDNVRPL SYPDSDAVLI CFDISRPETL DSVLKKWKGE IQEFCPNTKM LLVGCKSDLR TDVSTLVELS NHRQTPVSYD QGANMAKQIG AATYIECSAL QSENSVRDIF HVATLACVNK TNKNVKRNKS QRATKRISHM PSRPELSAVA TDLRKDKAKS CTVM
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