About Protein transport protein Sec61 subunit alpha isoform 1
Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1) is a protein
from Homo sapiens identified by UniProt accession
P61619, 476 residues long.
MolForge cross-references it against 0 known binders and
219 disease associations.
Target properties
| Protein name | Protein transport protein Sec61 subunit alpha isoform 1 |
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| UniProt accession | P61619 |
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| Gene | SEC61A1 |
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| Organism | Homo sapiens |
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| Length | 476 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (219)
Diseases linked to this target (Open Targets).
- hyperuricemic nephropathy, familial juvenile type 4 · score 0.71
- SEC61A1 deficiency · score 0.51
- severe congenital neutropenia · score 0.42
- autosomal dominant polycystic liver disease · score 0.29
- Isolated polycystic liver disease · score 0.29
- Decreased circulating antibody level · score 0.27
- genetic disorder · score 0.19
- chronic kidney disease · score 0.19
- interstitial nephritis · score 0.18
- Cystic Kidney Disease · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P61619-F1 | alphafold | PREDICTED | 72.94 | — |
Amino-acid sequence (476 residues)
MAIKFLEVIK PFCVILPEIQ KPERKIQFKE KVLWTAITLF IFLVCCQIPL FGIMSSDSAD PFYWMRVILA SNRGTLMELG ISPIVTSGLI MQLLAGAKII EVGDTPKDRA LFNGAQKLFG MIITIGQSIV YVMTGMYGDP SEMGAGICLL ITIQLFVAGL IVLLLDELLQ KGYGLGSGIS LFIATNICET IVWKAFSPTT VNTGRGMEFE GAIIALFHLL ATRTDKVRAL REAFYRQNLP NLMNLIATIF VFAVVIYFQG FRVDLPIKSA RYRGQYNTYP IKLFYTSNIP IILQSALVSN LYVISQMLSA RFSGNLLVSL LGTWSDTSSG GPARAYPVGG LCYYLSPPES FGSVLEDPVH AVVYIVFMLG SCAFFSKTWI EVSGSSAKDV AKQLKEQQMV MRGHRETSMV HELNRYIPTA AAFGGLCIGA LSVLADFLGA IGSGTGILLA VTIIYQYFEI FVKEQSEVGS MGALLF
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