About Prefoldin subunit 3
Prefoldin subunit 3 (VBP1) is a protein
from Homo sapiens identified by UniProt accession
P61758, 197 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Prefoldin subunit 3 |
|---|
| UniProt accession | P61758 |
|---|
| Gene | VBP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 197 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (33)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- head and neck squamous cell carcinoma · score 0.23
- lung adenocarcinoma · score 0.23
- endometrial cancer · score 0.23
- breast adenocarcinoma · score 0.23
- ependymoma · score 0.11
- esophageal squamous cell carcinoma · score 0.06
- neoplasm · score 0.03
- nonpapillary renal cell carcinoma · score 0.02
- renal cell carcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P61758-F1 | alphafold | PREDICTED | 86.02 | — |
Amino-acid sequence (197 residues)
MAAVKDSCGK GEMATGNGRR LHLGIPEAVF VEDVDSFMKQ PGNETADTVL KKLDEQYQKY KFMELNLAQK KRRLKGQIPE IKQTLEILKY MQKKKESTNS METRFLLADN LYCKASVPPT DKVCLWLGAN VMLEYDIDEA QALLEKNLST ATKNLDSLEE DLDFLRDQFT TTEVNMARVY NWDVKRRNKD DSTKNKA
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