Beta-2-microglobulin (B2M)

About Beta-2-microglobulin

Beta-2-microglobulin (B2M) is a protein from Homo sapiens identified by UniProt accession P61769, 119 residues long. MolForge cross-references it against 0 known binders and 964 disease associations.

Target properties

Protein name	Beta-2-microglobulin
UniProt accession	P61769
Gene	B2M
Organism	Homo sapiens
Length	119 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (964)

Diseases linked to this target (Open Targets).

Immunodeficiency by defective expression of HLA class 1 · score 0.64
diffuse large B-cell lymphoma · score 0.59
Familial renal amyloidosis · score 0.55
familial visceral amyloidosis · score 0.55
HIV infection · score 0.53
non-Hodgkins lymphoma · score 0.51
cutaneous melanoma · score 0.47
COVID-19 · score 0.46
AL amyloidosis · score 0.46
head and neck squamous cell carcinoma · score 0.46

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P61769-F1	alphafold	PREDICTED	94.04	—

Amino-acid sequence (119 residues)

MSRSVALAVL ALLSLSGLEA IQRTPKIQVY SRHPAENGKS NFLNCYVSGF HPSDIEVDLL KNGERIEKVE HSDLSFSKDW SFYLLYYTEF TPTEKDEYAC RVNHVTLSQP KIVKWDRDM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards