Transforming growth factor beta-2 proprotein (TGFB2)

About Transforming growth factor beta-2 proprotein

Transforming growth factor beta-2 proprotein (TGFB2) is a protein from Homo sapiens identified by UniProt accession P61812, 414 residues long. MolForge cross-references it against 0 known binders and 1,056 disease associations.

Target properties

Protein name	Transforming growth factor beta-2 proprotein
UniProt accession	P61812
Gene	TGFB2
Organism	Homo sapiens
Length	414 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (1056)

Diseases linked to this target (Open Targets).

Loeys-Dietz syndrome · score 0.76
familial thoracic aortic aneurysm and aortic dissection · score 0.70
FEV/FVC ratio · score 0.56
Rare disease with thoracic aortic aneurysm and aortic dissection · score 0.56
myelodysplastic syndrome · score 0.55
body height · score 0.50
BMI-adjusted waist circumference · score 0.49
vital capacity · score 0.49
forced expiratory volume · score 0.48
lean body mass · score 0.48

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P61812-F1	alphafold	PREDICTED	80.10	—

Amino-acid sequence (414 residues)

MHYCVLSAFL ILHLVTVALS LSTCSTLDMD QFMRKRIEAI RGQILSKLKL TSPPEDYPEP EEVPPEVISI YNSTRDLLQE KASRRAAACE RERSDEEYYA KEVYKIDMPP FFPSENAIPP TFYRPYFRIV RFDVSAMEKN ASNLVKAEFR VFRLQNPKAR VPEQRIELYQ ILKSKDLTSP TQRYIDSKVV KTRAEGEWLS FDVTDAVHEW LHHKDRNLGF KISLHCPCCT FVPSNNYIIP NKSEELEARF AGIDGTSTYT SGDQKTIKST RKKNSGKTPH LLLMLLPSYR LESQQTNRRK KRALDAAYCF RNVQDNCCLR PLYIDFKRDL GWKWIHEPKG YNANFCAGAC PYLWSSDTQH SRVLSLYNTI NPEASASPCC VSQDLEPLTI LYYIGKTPKI EQLSNMIVKS CKCS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards