NPC intracellular cholesterol transporter 2 (NPC2)

About NPC intracellular cholesterol transporter 2

NPC intracellular cholesterol transporter 2 (NPC2) is a protein from Homo sapiens identified by UniProt accession P61916, 151 residues long. MolForge cross-references it against 0 known binders and 374 disease associations.

Target properties

Protein name	NPC intracellular cholesterol transporter 2
UniProt accession	P61916
Gene	NPC2
Organism	Homo sapiens
Length	151 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (374)

Diseases linked to this target (Open Targets).

Niemann-Pick disease type C · score 0.78
Niemann-Pick disease · score 0.55
genetic disorder · score 0.49
Dystonia · score 0.37
Niemann-Pick disease type C, late infantile neurologic onset · score 0.37
Niemann-Pick disease type C, severe early infantile neurologic onset · score 0.37
Niemann-Pick disease type C, severe perinatal form · score 0.37
Niemann-Pick disease type C, juvenile neurologic onset · score 0.37
Niemann-Pick disease type C, adult neurologic onset · score 0.37
intraocular pressure measurement · score 0.35

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P61916-F1	alphafold	PREDICTED	92.88	—

Amino-acid sequence (151 residues)

MRFLAATFLL LALSTAAQAE PVQFKDCGSV DGVIKEVNVS PCPTQPCQLS KGQSYSVNVT FTSNIQSKSS KAVVHGILMG VPVPFPIPEP DGCKSGINCP IQKDKTYSYL NKLPVKSEYP SIKLVVEWQL QDDKNQSLFC WEIPVQIVSH L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards