About Coatomer subunit zeta-1
Coatomer subunit zeta-1 (COPZ1) is a protein
from Homo sapiens identified by UniProt accession
P61923, 177 residues long.
MolForge cross-references it against 0 known binders and
70 disease associations.
Target properties
| Protein name | Coatomer subunit zeta-1 |
|---|
| UniProt accession | P61923 |
|---|
| Gene | COPZ1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 177 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (70)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- Parkinson disease · score 0.46
- Alzheimer disease · score 0.46
- multiple sclerosis · score 0.46
- lysosomal storage disease · score 0.46
- platelet count · score 0.33
- mean platelet volume · score 0.31
- blood protein measurement · score 0.31
- Red cell distribution width · score 0.30
- platelet component distribution width · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P61923-F1 | alphafold | PREDICTED | 89.32 | — |
Amino-acid sequence (177 residues)
MEALILEPSL YTVKAILILD NDGDRLFAKY YDDTYPSVKE QKAFEKNIFN KTHRTDSEIA LLEGLTVVYK SSIDLYFYVI GSSYENELML MAVLNCLFDS LSQMLRKNVE KRALLENMEG LFLAVDEIVD GGVILESDPQ QVVHRVALRG EDVPLTEQTV SQVLQSAKEQ IKWSLLR
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