cAMP-dependent protein kinase inhibitor alpha (PKIA)

About cAMP-dependent protein kinase inhibitor alpha

cAMP-dependent protein kinase inhibitor alpha (PKIA) is a protein from Homo sapiens identified by UniProt accession P61925, 76 residues long. MolForge cross-references it against 0 known binders and 104 disease associations.

Target properties

Protein name	cAMP-dependent protein kinase inhibitor alpha
UniProt accession	P61925
Gene	PKIA
Organism	Homo sapiens
Length	76 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (104)

Diseases linked to this target (Open Targets).

lymphocyte count · score 0.31
PHF-tau measurement · score 0.31
neutrophil percentage of leukocytes · score 0.30
lymphocyte percentage of leukocytes · score 0.30
multiple sclerosis · score 0.28
refractive error measurement · score 0.26
leukocyte count · score 0.26
neutrophil count · score 0.25
reticulocyte count · score 0.24
monocyte count · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P61925-F1	alphafold	PREDICTED	65.29	—

Amino-acid sequence (76 residues)

MTDVETTYAD FIASGRTGRR NAIHDILVSS ASGNSNELAL KLAGLDINKT EGEEDAQRSS TEQSGEAQGE AAKSES

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards