Guanine nucleotide-binding protein G(I)/G(S)/G(O)…

About Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 (GNG11) is a protein from Homo sapiens identified by UniProt accession P61952, 73 residues long. MolForge cross-references it against 0 known binders and 77 disease associations.

Target properties

Protein name	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
UniProt accession	P61952
Gene	GNG11
Organism	Homo sapiens
Length	73 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (77)

Diseases linked to this target (Open Targets).

heart rate variability measurement · score 0.36
heart rate response to recovery post exercise · score 0.35
heart rate · score 0.29
breast adenocarcinoma · score 0.28
diastolic blood pressure · score 0.27
head and neck squamous cell carcinoma · score 0.26
lung adenocarcinoma · score 0.24
resting heart rate · score 0.24
diet measurement · score 0.23
esophageal cancer · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P61952-F1	alphafold	PREDICTED	88.06	—

Amino-acid sequence (73 residues)

MPALHIEDLP EKEKLKMEVE QLRKEVKLQR QQVSKCSEEI KNYIEERSGE DPLVKGIPED KNPFKEKGSC VIS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 (GNG11)