DDB1- and CUL4-associated factor 7 (DCAF7)

About DDB1- and CUL4-associated factor 7

DDB1- and CUL4-associated factor 7 (DCAF7) is a protein from Homo sapiens identified by UniProt accession P61962, 342 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.

Target properties

Protein name	DDB1- and CUL4-associated factor 7
UniProt accession	P61962
Gene	DCAF7
Organism	Homo sapiens
Length	342 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (51)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.56
lysosomal storage disease · score 0.37
lung adenocarcinoma · score 0.25
head and neck squamous cell carcinoma · score 0.25
endometrial cancer · score 0.25
breast adenocarcinoma · score 0.25
urinary bladder cancer · score 0.24
body mass index · score 0.22
type 2 diabetes mellitus · score 0.18
squamous cell lung carcinoma · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P61962-F1	alphafold	PREDICTED	93.23	—

Amino-acid sequence (342 residues)

MSLHGKRKEI YKYEAPWTVY AMNWSVRPDK RFRLALGSFV EEYNNKVQLV GLDEESSEFI CRNTFDHPYP TTKLMWIPDT KGVYPDLLAT SGDYLRVWRV GETETRLECL LNNNKNSDFC APLTSFDWNE VDPYLLGTSS IDTTCTIWGL ETGQVLGRVN LVSGHVKTQL IAHDKEVYDI AFSRAGGGRD MFASVGADGS VRMFDLRHLE HSTIIYEDPQ HHPLLRLCWN KQDPNYLATM AMDGMEVVIL DVRVPCTPVA RLNNHRACVN GIAWAPHSSC HICTAADDHQ ALIWDIQQMP RAIEDPILAY TAEGEINNVQ WASTQPDWIA ICYNNCLEIL RV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards