WD repeat-containing protein 5 (WDR5)

About WD repeat-containing protein 5

WD repeat-containing protein 5 (WDR5) is a protein from Homo sapiens identified by UniProt accession P61964, 334 residues long. MolForge cross-references it against 0 known binders and 136 disease associations.

Target properties

Protein name	WD repeat-containing protein 5
UniProt accession	P61964
Gene	WDR5
Organism	Homo sapiens
Length	334 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (136)

Diseases linked to this target (Open Targets).

body height · score 0.34
breast adenocarcinoma · score 0.26
reticulocyte count · score 0.26
waist-hip ratio · score 0.26
sitting height measurement · score 0.25
endometrial cancer · score 0.25
Red cell distribution width · score 0.24
sex hormone-binding globulin measurement · score 0.23
BMI-adjusted waist-hip ratio · score 0.23
Neurodevelopmental disorder · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P61964-F1	alphafold	PREDICTED	93.34	—

Amino-acid sequence (334 residues)

MATEEKKPET EAARAQPTPS SSATQSKPTP VKPNYALKFT LAGHTKAVSS VKFSPNGEWL ASSSADKLIK IWGAYDGKFE KTISGHKLGI SDVAWSSDSN LLVSASDDKT LKIWDVSSGK CLKTLKGHSN YVFCCNFNPQ SNLIVSGSFD ESVRIWDVKT GKCLKTLPAH SDPVSAVHFN RDGSLIVSSS YDGLCRIWDT ASGQCLKTLI DDDNPPVSFV KFSPNGKYIL AATLDNTLKL WDYSKGKCLK TYTGHKNEKY CIFANFSVTG GKWIVSGSED NLVYIWNLQT KEIVQKLQGH TDVVISTACH PTENIIASAA LENDKTIKLW KSDC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards