AP-1 complex subunit sigma-1A (AP1S1)

About AP-1 complex subunit sigma-1A

AP-1 complex subunit sigma-1A (AP1S1) is a protein from Homo sapiens identified by UniProt accession P61966, 158 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.

Target properties

Protein name	AP-1 complex subunit sigma-1A
UniProt accession	P61966
Gene	AP1S1
Organism	Homo sapiens
Length	158 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (45)

Diseases linked to this target (Open Targets).

MEDNIK syndrome · score 0.76
HIV infection · score 0.50
neurodegenerative disease · score 0.34
genetic disorder · score 0.32
body mass index · score 0.26
vitamin D measurement · score 0.21
smoking status measurement · score 0.17
sex hormone-binding globulin measurement · score 0.17
esophageal squamous cell carcinoma · score 0.07
breast cancer · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P61966-F1	alphafold	PREDICTED	94.55	—

Amino-acid sequence (158 residues)

MMRFMLLFSR QGKLRLQKWY LATSDKERKK MVRELMQVVL ARKPKMCSFL EWRDLKVVYK RYASLYFCCA IEGQDNELIT LELIHRYVEL LDKYFGSVCE LDIIFNFEKA YFILDEFLMG GDVQDTSKKS VLKAIEQADL LQEEDESPRS VLEEMGLA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards