About Heterogeneous nuclear ribonucleoprotein K
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) is a protein
from Homo sapiens identified by UniProt accession
P61978, 463 residues long.
MolForge cross-references it against 0 known binders and
248 disease associations.
Target properties
| Protein name | Heterogeneous nuclear ribonucleoprotein K |
|---|
| UniProt accession | P61978 |
|---|
| Gene | HNRNPK |
|---|
| Organism | Homo sapiens |
|---|
| Length | 463 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (248)
Diseases linked to this target (Open Targets).
- Au-Kline syndrome · score 0.79
- genetic disorder · score 0.50
- neurodegenerative disease · score 0.46
- Intellectual disability · score 0.45
- viral disease · score 0.37
- infectious disease · score 0.37
- neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-hip dysplasia syndrome · score 0.37
- heel bone mineral density · score 0.27
- Generalized hypotonia · score 0.27
- sex hormone-binding globulin measurement · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P61978-F1 | alphafold | PREDICTED | 64.38 | — |
Amino-acid sequence (463 residues)
METEQPEETF PNTETNGEFG KRPAEDMEEE QAFKRSRNTD EMVELRILLQ SKNAGAVIGK GGKNIKALRT DYNASVSVPD SSGPERILSI SADIETIGEI LKKIIPTLEE GLQLPSPTAT SQLPLESDAV ECLNYQHYKG SDFDCELRLL IHQSLAGGII GVKGAKIKEL RENTQTTIKL FQECCPHSTD RVVLIGGKPD RVVECIKIIL DLISESPIKG RAQPYDPNFY DETYDYGGFT MMFDDRRGRP VGFPMRGRGG FDRMPPGRGG RPMPPSRRDY DDMSPRRGPP PPPPGRGGRG GSRARNLPLP PPPPPRGGDL MAYDRRGRPG DRYDGMVGFS ADETWDSAID TWSPSEWQMA YEPQGGSGYD YSYAGGRGSY GDLGGPIITT QVTIPKDLAG SIIGKGGQRI KQIRHESGAS IKIDEPLEGS EDRIITITGT QDQIQNAQYL LQNSVKQYSG KFF
Explore Heterogeneous nuclear ribonucleoprotein K with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets