About 14-3-3 protein gamma
14-3-3 protein gamma (YWHAG) is a protein
from Homo sapiens identified by UniProt accession
P61981, 247 residues long.
MolForge cross-references it against 0 known binders and
115 disease associations.
Target properties
| Protein name | 14-3-3 protein gamma |
|---|
| UniProt accession | P61981 |
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| Gene | YWHAG |
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| Organism | Homo sapiens |
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| Length | 247 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (115)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy · score 0.53
- undetermined early-onset epileptic encephalopathy · score 0.46
- Intellectual disability · score 0.46
- genetic disorder · score 0.39
- Seizure · score 0.37
- severe acute respiratory syndrome · score 0.37
- COVID-19 · score 0.37
- Microcephaly · score 0.34
- Constipation · score 0.34
- Spasticity · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P61981-F1 | alphafold | PREDICTED | 94.22 | — |
Amino-acid sequence (247 residues)
MVDREQLVQK ARLAEQAERY DDMAAAMKNV TELNEPLSNE ERNLLSVAYK NVVGARRSSW RVISSIEQKT SADGNEKKIE MVRAYREKIE KELEAVCQDV LSLLDNYLIK NCSETQYESK VFYLKMKGDY YRYLAEVATG EKRATVVESS EKAYSEAHEI SKEHMQPTHP IRLGLALNYS VFYYEIQNAP EQACHLAKTA FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDD DGGEGNN
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