Ubiquitin carboxyl-terminal hydrolase 46 (USP46)

About Ubiquitin carboxyl-terminal hydrolase 46

Ubiquitin carboxyl-terminal hydrolase 46 (USP46) is a protein from Homo sapiens identified by UniProt accession P62068, 366 residues long. MolForge cross-references it against 0 known binders and 89 disease associations.

Target properties

Protein name	Ubiquitin carboxyl-terminal hydrolase 46
UniProt accession	P62068
Gene	USP46
Organism	Homo sapiens
Length	366 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (89)

Diseases linked to this target (Open Targets).

body mass index · score 0.21
adult onset asthma · score 0.16
platelet count · score 0.13
major depressive disorder · score 0.08
Asperger syndrome · score 0.05
neoplasm · score 0.05
dehydrated hereditary stomatocytosis · score 0.05
Adult-onset autosomal recessive sideroblastic anemia · score 0.05
glioblastoma multiforme · score 0.05
Familial hemophagocytic lymphohistiocytosis · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P62068-F1	alphafold	PREDICTED	89.52	—

Amino-acid sequence (366 residues)

MTVRNIASIC NMGTNASALE KDIGPEQFPI NEHYFGLVNF GNTCYCNSVL QALYFCRPFR ENVLAYKAQQ KKKENLLTCL ADLFHSIATQ KKKVGVIPPK KFISRLRKEN DLFDNYMQQD AHEFLNYLLN TIADILQEEK KQEKQNGKLK NGNMNEPAEN NKPELTWVHE IFQGTLTNET RCLNCETVSS KDEDFLDLSV DVEQNTSITH CLRDFSNTET LCSEQKYYCE TCCSKQEAQK RMRVKKLPMI LALHLKRFKY MEQLHRYTKL SYRVVFPLEL RLFNTSSDAV NLDRMYDLVA VVVHCGSGPN RGHYITIVKS HGFWLLFDDD IVEKIDAQAI EEFYGLTSDI SKNSESGYIL FYQSRE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards