About Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) is a protein
from Homo sapiens identified by UniProt accession
P62136, 330 residues long.
MolForge cross-references it against 0 known binders and
120 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit |
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| UniProt accession | P62136 |
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| Gene | PPP1CA |
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| Organism | Homo sapiens |
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| Length | 330 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (120)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- lysosomal storage disease · score 0.35
- Alzheimer disease · score 0.33
- Parkinson disease · score 0.33
- multiple sclerosis · score 0.33
- mean platelet volume · score 0.11
- mean corpuscular volume · score 0.11
- endometrial cancer · score 0.09
- mean reticulocyte volume · score 0.09
- mean corpuscular hemoglobin concentration · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P62136-F1 | alphafold | PREDICTED | 91.22 | — |
Amino-acid sequence (330 residues)
MSDSEKLNLD SIIGRLLEVQ GSRPGKNVQL TENEIRGLCL KSREIFLSQP ILLELEAPLK ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS LETICLLLAY KIKYPENFFL LRGNHECASI NRIYGFYDEC KRRYNIKLWK TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL QSMEQIRRIM RPTDVPDQGL LCDLLWSDPD KDVQGWGEND RGVSFTFGAE VVAKFLHKHD LDLICRAHQV VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAD KNKGKYGQFS GLNPGGRPIT PPRNSAKAKK
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