About Serine/threonine-protein phosphatase PP1-beta catalytic subunit
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB) is a protein
from Homo sapiens identified by UniProt accession
P62140, 327 residues long.
MolForge cross-references it against 0 known binders and
333 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase PP1-beta catalytic subunit |
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| UniProt accession | P62140 |
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| Gene | PPP1CB |
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| Organism | Homo sapiens |
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| Length | 327 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (333)
Diseases linked to this target (Open Targets).
- Noonan syndrome-like disorder with loose anagen hair · score 0.77
- Noonan syndrome · score 0.57
- neurodegenerative disease · score 0.56
- neuroinflammatory disorder · score 0.45
- Abnormality of the cardiovascular system · score 0.44
- genetic disorder · score 0.37
- esophageal carcinoma · score 0.37
- lysosomal storage disease · score 0.36
- Parkinson disease · score 0.36
- multiple sclerosis · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P62140-F1 | alphafold | PREDICTED | 91.63 | — |
Amino-acid sequence (327 residues)
MADGELNVDS LITRLLEVRG CRPGKIVQMT EAEVRGLCIK SREIFLSQPI LLELEAPLKI CGDIHGQYTD LLRLFEYGGF PPEANYLFLG DYVDRGKQSL ETICLLLAYK IKYPENFFLL RGNHECASIN RIYGFYDECK RRFNIKLWKT FTDCFNCLPI AAIVDEKIFC CHGGLSPDLQ SMEQIRRIMR PTDVPDTGLL CDLLWSDPDK DVQGWGENDR GVSFTFGADV VSKFLNRHDL DLICRAHQVV EDGYEFFAKR QLVTLFSAPN YCGEFDNAGG MMSVDETLMC SFQILKPSEK KAKYQYGGLN SGRPVTPPRT ANPPKKR
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