26S proteasome regulatory subunit 4 (PSMC1)

About 26S proteasome regulatory subunit 4

26S proteasome regulatory subunit 4 (PSMC1) is a protein from Homo sapiens identified by UniProt accession P62191, 440 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

Target properties

Protein name	26S proteasome regulatory subunit 4
UniProt accession	P62191
Gene	PSMC1
Organism	Homo sapiens
Length	440 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (48)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.47
HIV infection · score 0.46
neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss · score 0.45
lung adenocarcinoma · score 0.30
glioblastoma multiforme · score 0.30
endometrial cancer · score 0.29
clear cell renal carcinoma · score 0.27
gastric adenocarcinoma · score 0.27
hepatocellular carcinoma · score 0.19
prostate carcinoma · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P62191-F1	alphafold	PREDICTED	77.83	—

Amino-acid sequence (440 residues)

MGQSQSGGHG PGGGKKDDKD KKKKYEPPVP TRVGKKKKKT KGPDAASKLP LVTPHTQCRL KLLKLERIKD YLLMEEEFIR NQEQMKPLEE KQEEERSKVD DLRGTPMSVG TLEEIIDDNH AIVSTSVGSE HYVSILSFVD KDLLEPGCSV LLNHKVHAVI GVLMDDTDPL VTVMKVEKAP QETYADIGGL DNQIQEIKES VELPLTHPEY YEEMGIKPPK GVILYGPPGT GKTLLAKAVA NQTSATFLRV VGSELIQKYL GDGPKLVREL FRVAEEHAPS IVFIDEIDAI GTKRYDSNSG GEREIQRTML ELLNQLDGFD SRGDVKVIMA TNRIETLDPA LIRPGRIDRK IEFPLPDEKT KKRIFQIHTS RMTLADDVTL DDLIMAKDDL SGADIKAICT EAGLMALRER RMKVTNEDFK KSKENVLYKK QEGTPEGLYL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards