26S proteasome regulatory subunit 8 (PSMC5)

About 26S proteasome regulatory subunit 8

26S proteasome regulatory subunit 8 (PSMC5) is a protein from Homo sapiens identified by UniProt accession P62195, 406 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.

Target properties

Protein name	26S proteasome regulatory subunit 8
UniProt accession	P62195
Gene	PSMC5
Organism	Homo sapiens
Length	406 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (85)

Diseases linked to this target (Open Targets).

HIV infection · score 0.46
neurodegenerative disease · score 0.31
ovarian cancer · score 0.29
chronic lymphocytic leukemia · score 0.28
head and neck squamous cell carcinoma · score 0.28
squamous cell lung carcinoma · score 0.28
clear cell renal carcinoma · score 0.27
gastric adenocarcinoma · score 0.27
multiple myeloma · score 0.24
hemoglobin measurement · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P62195-F1	alphafold	PREDICTED	82.15	—

Amino-acid sequence (406 residues)

MALDGPEQME LEEGKAGSGL RQYYLSKIEE LQLIVNDKSQ NLRRLQAQRN ELNAKVRLLR EELQLLQEQG SYVGEVVRAM DKKKVLVKVH PEGKFVVDVD KNIDINDVTP NCRVALRNDS YTLHKILPNK VDPLVSLMMV EKVPDSTYEM IGGLDKQIKE IKEVIELPVK HPELFEALGI AQPKGVLLYG PPGTGKTLLA RAVAHHTDCT FIRVSGSELV QKFIGEGARM VRELFVMARE HAPSIIFMDE IDSIGSSRLE GGSGGDSEVQ RTMLELLNQL DGFEATKNIK VIMATNRIDI LDSALLRPGR IDRKIEFPPP NEEARLDILK IHSRKMNLTR GINLRKIAEL MPGASGAEVK GVCTEAGMYA LRERRVHVTQ EDFEMAVAKV MQKDSEKNMS IKKLWK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards