Small ribosomal subunit protein uS8 (RPS15A)

About Small ribosomal subunit protein uS8

Small ribosomal subunit protein uS8 (RPS15A) is a protein from Homo sapiens identified by UniProt accession P62244, 130 residues long. MolForge cross-references it against 0 known binders and 82 disease associations.

Target properties

Protein name	Small ribosomal subunit protein uS8
UniProt accession	P62244
Gene	RPS15A
Organism	Homo sapiens
Length	130 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (82)

Diseases linked to this target (Open Targets).

Duchenne muscular dystrophy · score 0.50
cystic fibrosis · score 0.50
influenza · score 0.46
Blackfan-Diamond anemia · score 0.45
COVID-19 · score 0.37
Diamond-Blackfan anemia · score 0.37
severe acute respiratory syndrome · score 0.37
neurodegenerative disease · score 0.33
Becker muscular dystrophy · score 0.29
qualitative or quantitative defects of dystrophin · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P62244-F1	alphafold	PREDICTED	93.07	—

Amino-acid sequence (130 residues)

MVRMNVLADA LKSINNAEKR GKRQVLIRPC SKVIVRFLTV MMKHGYIGEF EIIDDHRAGK IVVNLTGRLN KCGVISPRFD VQLKDLEKWQ NNLLPSRQFG FIVLTTSAGI MDHEEARRKH TGGKILGFFF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards