About 14-3-3 protein epsilon
14-3-3 protein epsilon (YWHAE) is a protein
from Homo sapiens identified by UniProt accession
P62258, 255 residues long.
MolForge cross-references it against 0 known binders and
312 disease associations.
Target properties
| Protein name | 14-3-3 protein epsilon |
|---|
| UniProt accession | P62258 |
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| Gene | YWHAE |
|---|
| Organism | Homo sapiens |
|---|
| Length | 255 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (312)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- schizophrenia · score 0.38
- mean platelet volume · score 0.38
- endometrial stromal sarcoma · score 0.38
- clear cell sarcoma · score 0.37
- COVID-19 · score 0.37
- leiomyosarcoma · score 0.37
- leiomyoma · score 0.37
- malignant peripheral nerve sheath tumor · score 0.37
- bile duct carcinoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P62258-F1 | alphafold | PREDICTED | 92.88 | — |
Amino-acid sequence (255 residues)
MDDREDLVYQ AKLAEQAERY DEMVESMKKV AGMDVELTVE ERNLLSVAYK NVIGARRASW RIISSIEQKE ENKGGEDKLK MIREYRQMVE TELKLICCDI LDVLDKHLIP AANTGESKVF YYKMKGDYHR YLAEFATGND RKEAAENSLV AYKAASDIAM TELPPTHPIR LGLALNFSVF YYEILNSPDR ACRLAKAAFD DAIAELDTLS EESYKDSTLI MQLLRDNLTL WTSDMQGDGE EQNKEALQDV EDENQ
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