ADP-ribosylation factor 6 (ARF6)

About ADP-ribosylation factor 6

ADP-ribosylation factor 6 (ARF6) is a protein from Homo sapiens identified by UniProt accession P62330, 175 residues long. MolForge cross-references it against 0 known binders and 184 disease associations.

Target properties

Protein name	ADP-ribosylation factor 6
UniProt accession	P62330
Gene	ARF6
Organism	Homo sapiens
Length	175 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (184)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.44
serum gamma-glutamyl transferase measurement · score 0.27
lymphocyte count · score 0.17
head and neck squamous cell carcinoma · score 0.17
hepatocellular carcinoma · score 0.10
bone density · score 0.10
urate measurement · score 0.10
neoplasm · score 0.10
cancer · score 0.09
cyst · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P62330-F1	alphafold	PREDICTED	94.03	—

Amino-acid sequence (175 residues)

MGKVLSKIFG NKEMRILMLG LDAAGKTTIL YKLKLGQSVT TIPTVGFNVE TVTYKNVKFN VWDVGGQDKI RPLWRHYYTG TQGLIFVVDC ADRDRIDEAR QELHRIINDR EMRDAIILIF ANKQDLPDAM KPHEIQEKLG LTRIRDRNWY VQPSCATSGD GLYEGLTWLT SNYKS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards