26S proteasome regulatory subunit 10B (PSMC6)

About 26S proteasome regulatory subunit 10B

26S proteasome regulatory subunit 10B (PSMC6) is a protein from Homo sapiens identified by UniProt accession P62333, 389 residues long. MolForge cross-references it against 0 known binders and 87 disease associations.

Target properties

Protein name	26S proteasome regulatory subunit 10B
UniProt accession	P62333
Gene	PSMC6
Organism	Homo sapiens
Length	389 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (87)

Diseases linked to this target (Open Targets).

HIV infection · score 0.46
severe acute respiratory syndrome · score 0.37
lung adenocarcinoma · score 0.30
breast adenocarcinoma · score 0.30
low grade glioma · score 0.29
endometrial cancer · score 0.29
urinary bladder cancer · score 0.28
squamous cell lung carcinoma · score 0.28
head and neck squamous cell carcinoma · score 0.28
clear cell renal carcinoma · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P62333-F1	alphafold	PREDICTED	86.88	—

Amino-acid sequence (389 residues)

MADPRDKALQ DYRKKLLEHK EIDGRLKELR EQLKELTKQY EKSENDLKAL QSVGQIVGEV LKQLTEEKFI VKATNGPRYV VGCRRQLDKS KLKPGTRVAL DMTTLTIMRY LPREVDPLVY NMSHEDPGNV SYSEIGGLSE QIRELREVIE LPLTNPELFQ RVGIIPPKGC LLYGPPGTGK TLLARAVASQ LDCNFLKVVS SSIVDKYIGE SARLIREMFN YARDHQPCII FMDEIDAIGG RRFSEGTSAD REIQRTLMEL LNQMDGFDTL HRVKMIMATN RPDTLDPALL RPGRLDRKIH IDLPNEQARL DILKIHAGPI TKHGEIDYEA IVKLSDGFNG ADLRNVCTEA GMFAIRADHD FVVQEDFMKA VRKVADSKKL ESKLDYKPV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards