About TATA box-binding protein-like 1
TATA box-binding protein-like 1 (TBPL1) is a protein
from Homo sapiens identified by UniProt accession
P62380, 186 residues long.
MolForge cross-references it against 0 known binders and
148 disease associations.
Target properties
| Protein name | TATA box-binding protein-like 1 |
|---|
| UniProt accession | P62380 |
|---|
| Gene | TBPL1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 186 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (148)
Diseases linked to this target (Open Targets).
- mean corpuscular hemoglobin · score 0.29
- C-reactive protein measurement · score 0.26
- arterial stiffness measurement · score 0.22
- systolic blood pressure · score 0.11
- azoospermia · score 0.10
- partial chromosome Y deletion · score 0.09
- spermatogenic failure 8 · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- spermatogenic failures 50 · score 0.09
- spermatogenic failure 25 · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P62380-F1 | alphafold | PREDICTED | 95.02 | — |
Amino-acid sequence (186 residues)
MDADSDVALD ILITNVVCVF RTRCHLNLRK IALEGANVIY KRDVGKVLMK LRKPRITATI WSSGKIICTG ATSEEEAKFG ARRLARSLQK LGFQVIFTDF KVVNVLAVCN MPFEIRLPEF TKNNRPHASY EPELHPAVCY RIKSLRATLQ IFSTGSITVT GPNVKAVATA VEQIYPFVFE SRKEIL
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