DNA-directed RNA polymerase II subunit RPB7 (POLR2G)

About DNA-directed RNA polymerase II subunit RPB7

DNA-directed RNA polymerase II subunit RPB7 (POLR2G) is a protein from Homo sapiens identified by UniProt accession P62487, 172 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.

Target properties

Protein name	DNA-directed RNA polymerase II subunit RPB7
UniProt accession	P62487
Gene	POLR2G
Organism	Homo sapiens
Length	172 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (16)

Diseases linked to this target (Open Targets).

HIV infection · score 0.60
acrocephalosyndactyly · score 0.37
influenza · score 0.37
lung adenocarcinoma · score 0.27
low grade glioma · score 0.26
head and neck squamous cell carcinoma · score 0.26
cutaneous melanoma · score 0.24
neoplasm · score 0.03
gestational diabetes · score 0.01
hepatocellular carcinoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P62487-F1	alphafold	PREDICTED	95.60	—

Amino-acid sequence (172 residues)

MFYHISLEHE ILLHPRYFGP NLLNTVKQKL FTEVEGTCTG KYGFVIAVTT IDNIGAGVIQ PGRGFVLYPV KYKAIVFRPF KGEVVDAVVT QVNKVGLFTE IGPMSCFISR HSIPSEMEFD PNSNPPCYKT MDEDIVIQQD DEIRLKIVGT RVDKNDIFAI GSLMDDYLGL VS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards