About Ras-related protein Rab-11A
Ras-related protein Rab-11A (RAB11A) is a protein
from Homo sapiens identified by UniProt accession
P62491, 216 residues long.
MolForge cross-references it against 0 known binders and
201 disease associations.
Target properties
| Protein name | Ras-related protein Rab-11A |
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| UniProt accession | P62491 |
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| Gene | RAB11A |
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| Organism | Homo sapiens |
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| Length | 216 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (201)
Diseases linked to this target (Open Targets).
- Intellectual disability · score 0.48
- Global developmental delay · score 0.42
- Microcephaly · score 0.37
- microcephaly · score 0.37
- autosomal dominant non-syndromic intellectual disability · score 0.37
- intellectual disability, autosomal dominant 56 · score 0.37
- mean corpuscular hemoglobin · score 0.27
- Delayed speech and language development · score 0.27
- Intellectual disability, mild · score 0.27
- Coarse facial features · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P62491-F1 | alphafold | PREDICTED | 87.19 | — |
Amino-acid sequence (216 residues)
MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT RSIQVDGKTI KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE NVERWLKELR DHADSNIVIM LVGNKSDLRH LRAVPTDEAR AFAEKNGLSF IETSALDSTN VEAAFQTILT EIYRIVSQKQ MSDRRENDMS PSNNVVPIHV PPTTENKPKV QCCQNI
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