Estrogen-related receptor gamma (ESRRG)

About Estrogen-related receptor gamma

Estrogen-related receptor gamma (ESRRG) is a protein from Homo sapiens identified by UniProt accession P62508, 458 residues long. MolForge cross-references it against 0 known binders and 312 disease associations.

Target properties

Protein name	Estrogen-related receptor gamma
UniProt accession	P62508
Gene	ESRRG
Organism	Homo sapiens
Length	458 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (312)

Diseases linked to this target (Open Targets).

hemoglobin measurement · score 0.44
hematocrit · score 0.42
calcium measurement · score 0.40
breast carcinoma · score 0.40
adolescent idiopathic scoliosis · score 0.38
red blood cell density measurement · score 0.38
erythrocyte count · score 0.35
FEV/FVC ratio · score 0.32
female reproductive system disease · score 0.32
dislocation · score 0.32

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P62508-F1	alphafold	PREDICTED	76.23	—

Amino-acid sequence (458 residues)

MDSVELCLPE SFSLHYEEEL LCRMSNKDRH IDSSCSSFIK TEPSSPASLT DSVNHHSPGG SSDASGSYSS TMNGHQNGLD SPPLYPSAPI LGGSGPVRKL YDDCSSTIVE DPQTKCEYML NSMPKRLCLV CGDIASGYHY GVASCEACKA FFKRTIQGNI EYSCPATNEC EITKRRRKSC QACRFMKCLK VGMLKEGVRL DRVRGGRQKY KRRIDAENSP YLNPQLVQPA KKPYNKIVSH LLVAEPEKIY AMPDPTVPDS DIKALTTLCD LADRELVVII GWAKHIPGFS TLSLADQMSL LQSAWMEILI LGVVYRSLSF EDELVYADDY IMDEDQSKLA GLLDLNNAIL QLVKKYKSMK LEKEEFVTLK AIALANSDSM HIEDVEAVQK LQDVLHEALQ DYEAGQHMED PRRAGKMLMT LPLLRQTSTK AVQHFYNIKL EGKVPMHKLF LEMLEAKV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards