About Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PPP2CB) is a protein
from Homo sapiens identified by UniProt accession
P62714, 309 residues long.
MolForge cross-references it against 0 known binders and
72 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform |
|---|
| UniProt accession | P62714 |
|---|
| Gene | PPP2CB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 309 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (72)
Diseases linked to this target (Open Targets).
- cancer · score 0.54
- chronic myelogenous leukemia · score 0.37
- breast adenocarcinoma · score 0.30
- lung adenocarcinoma · score 0.30
- cutaneous melanoma · score 0.29
- head and neck squamous cell carcinoma · score 0.27
- hepatocellular carcinoma · score 0.24
- esophageal cancer · score 0.23
- clear cell renal carcinoma · score 0.14
- glioblastoma multiforme · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P62714-F1 | alphafold | PREDICTED | 95.28 | — |
Amino-acid sequence (309 residues)
MDDKAFTKEL DQWVEQLNEC KQLNENQVRT LCEKAKEILT KESNVQEVRC PVTVCGDVHG QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYPER ITILRGNHES RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV TRRTPDYFL
Explore Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets