Actin, aortic smooth muscle (ACTA2)

About Actin, aortic smooth muscle

Actin, aortic smooth muscle (ACTA2) is a protein from Homo sapiens identified by UniProt accession P62736, 377 residues long. MolForge cross-references it against 0 known binders and 362 disease associations.

Target properties

Protein name	Actin, aortic smooth muscle
UniProt accession	P62736
Gene	ACTA2
Organism	Homo sapiens
Length	377 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (362)

Diseases linked to this target (Open Targets).

multisystemic smooth muscle dysfunction syndrome · score 0.79
aortic aneurysm, familial thoracic 6 · score 0.78
Moyamoya disease 5 · score 0.77
familial thoracic aortic aneurysm and aortic dissection · score 0.70
Rare disease with thoracic aortic aneurysm and aortic dissection · score 0.67
Rare genetic vascular disease · score 0.57
thoracic aortic aneurysm · score 0.54
Familial hemophagocytic lymphohistiocytosis · score 0.41
autoimmune lymphoproliferative syndrome · score 0.37
connective tissue disease · score 0.36

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P62736-F1	alphafold	PREDICTED	95.35	—

Amino-acid sequence (377 residues)

MCEEEDSTAL VCDNGSGLCK AGFAGDDAPR AVFPSIVGRP RHQGVMVGMG QKDSYVGDEA QSKRGILTLK YPIEHGIITN WDDMEKIWHH SFYNELRVAP EEHPTLLTEA PLNPKANREK MTQIMFETFN VPAMYVAIQA VLSLYASGRT TGIVLDSGDG VTHNVPIYEG YALPHAIMRL DLAGRDLTDY LMKILTERGY SFVTTAEREI VRDIKEKLCY VALDFENEMA TAASSSSLEK SYELPDGQVI TIGNERFRCP ETLFQPSFIG MESAGIHETT YNSIMKCDID IRKDLYANNV LSGGTTMYPG IADRMQKEIT ALAPSTMKIK IIAPPERKYS VWIGGSILAS LSTFQQMWIS KQEYDEAGPS IVHRKCF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards