Histone H4 (H4C1)

About Histone H4

Histone H4 (H4C1) is a protein from Homo sapiens identified by UniProt accession P62805, 103 residues long. MolForge cross-references it against 0 known binders and 482 disease associations.

Target properties

Protein name	Histone H4
UniProt accession	P62805
Gene	H4C1
Organism	Homo sapiens
Length	103 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (482)

Diseases linked to this target (Open Targets).

Tessadori-Van Haaften neurodevelopmental syndrome 3 · score 0.59
infectious disease · score 0.50
viral disease · score 0.50
breast carcinoma · score 0.39
cancer · score 0.38
melanoma · score 0.37
complex neurodevelopmental disorder · score 0.37
self reported educational attainment · score 0.30
Red cell distribution width · score 0.27
BMI-adjusted waist circumference · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P62805-F1	alphafold	PREDICTED	89.83	—

Amino-acid sequence (103 residues)

MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL IYEETRGVLK VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG FGG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards