About Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (GNB1) is a protein
from Homo sapiens identified by UniProt accession
P62873, 340 residues long.
MolForge cross-references it against 0 known binders and
215 disease associations.
Target properties
| Protein name | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 |
|---|
| UniProt accession | P62873 |
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| Gene | GNB1 |
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| Organism | Homo sapiens |
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| Length | 340 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (215)
Diseases linked to this target (Open Targets).
- intellectual disability, autosomal dominant 42 · score 0.82
- acute lymphoblastic leukemia · score 0.54
- Hypotonia · score 0.53
- Global developmental delay · score 0.53
- T-cell acute lymphoblastic leukemia · score 0.53
- Intellectual disability · score 0.52
- Seizure · score 0.52
- genetic disorder · score 0.51
- global developmental delay-neuro-ophthalmological abnormalities-seizures-intellectual disability syndrome · score 0.50
- Growth delay · score 0.49
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P62873-F1 | alphafold | PREDICTED | 97.06 | — |
Amino-acid sequence (340 residues)
MSELDQLRQE AEQLKNQIRD ARKACADATL SQITNNIDPV GRIQMRTRRT LRGHLAKIYA MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV MTCAYAPSGN YVACGGLDNI CSIYNLKTRE GNVRVSRELA GHTGYLSCCR FLDDNQIVTS SGDTTCALWD IETGQQTTTF TGHTGDVMSL SLAPDTRLFV SGACDASAKL WDVREGMCRQ TFTGHESDIN AICFFPNGNA FATGSDDATC RLFDLRADQE LMTYSHDNII CGITSVSFSK SGRLLLAGYD DFNCNVWDAL KADRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN
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